Yes, quite often. Big companies use low-code development for many practical things: internal portals, request systems, approval flows, reporting tools, dashboards, and service workflows. In other words, the kinds of applications that support daily operations but do not always justify a full custom build.
That does not mean it fits every enterprise case. If the system is central to the business, depends on unusual logic, or needs a level of freedom that a platform cannot really offer, low-code may stop being the right option. So the answer depends less on company size and more on the type of task.
Contact DigitalSuits if you hesitate whether low-code/no-code development is a valid option in your situation.